His battle with Shocker leads him through Grand Central Station, into the sewers and to a subway station, where Spider-Man defeats him in a climactic battle.
Meanwhile, the Shocker has just robbed a bank, and is driving away with his thugs as Spidey lands, only to be hit by Vulture. Spider-Man fights these robots and emerges victorious. Anxious to develop his Human Performance Enhancer Serum, the main goals of which are already exhibited by the super-hero, Osborn orders the capture of Spider-Man, deploying hunter-killer robots for this purpose. Meanwhile, Norman Osborn and OSCORP are investigating the appearance of this new hero. Peter vows to use his powers for good and to fight evil in Manhattan. Peter uses his new powers to track down and defeat the murderer. After competing in a wrestling match as Spider-Man, Peter is devastated when his Uncle Ben is killed by a car jacker. The game opens with an optional tutorial, narrated by Bruce Campbell, where Peter learns to use his powers and the player learns the controls of the game and how to read the HUD. Peter Parker develops super-spider powers after being bitten by a genetically altered spider.